Neuroimmunology.
Cellular/Molecular neurobiology.
My research interests focus on understanding the pathophysiological roles of neurovascular unit (NVU) in acute and chronic neurological disorders, such as stroke and Alzheimer’s disease.
The NVU is a functional unit composed of neurons and non-neuronal cells, such as vascular cells (endothelial cells, pericytes, and vascular smooth muscle cells) and glia (astrocytes, microglia, and oligodendrocytes). The interaction between all these cell types contributes to the maintenance of central nervous system homeostasis, while abnormal regulation may lead to cerebral dysfunction and diseases.
Representative Publications
Neuroprotective effects of MAGL (monoacylglycerol lipase) inhibitors in experimental ischemic stroke.
Choi SH, Arai AL, Mou Y, Kang B, Yen CC, Hallenbeck J, Silva AC
Stroke (2018)
Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer’s disease.
Choi SH, Aid S, Caracciolo L, Minami SS, Niikura T, Matsuoka Y, Turner RS, Mattson MP, Bosetti F
Journal of Neurochemistry (2013)
Inhibition of NADPH oxdiase promotes alternative and anti-inflammatory microglial activation.
Choi SH, Aid S, Kim HW, Jackson S, Bosetti F
Journal of Neurochemistry (2012)
Genetic deletion or pharmacological inhibition of cyclooxygenase 1 attenuate lipopolysaccharide-induced inflammatory response and brain injury.
Choi SH, Langenbach R, Bosetti F
FASEB Journal (2008)
Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in vivo: Role of microglial NADPH oxidase.
Choi SH, Lee DY, Kim SU, Jin BK
Journal of Neuroscience (2005)
Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo.
Choi SH, Joe EH, Kim SU, Jin BK
Journal of Neuroscience (2003)