Plasticity of Auditory Circuits
Trainees in Dr. Kandler's laboratory can engage in research projects investigating mechanisms of synaptic and neuronal plasticity in the auditory system. Our lab focuses on activity-dependent circuit refinement during development and on neuronal circuit changes that occur under pathological conditions (developmental deficits, hearing loss, and tinnitus).
We use a variety of electrophysiological, live-imaging, anatomical, and behavioral methods, which we applied to normal and genetically modified mice. Together with other auditory laboratories in the Department trainees are submerged in a rich interdisciplinary environment, trainees participate in joint lab-meetings, and frequently engage in ongoing collaborative projects (with Rubio-lab, Sadagopan-lab, Seal-lab).
To discuss possible research projects please email.
Mice Lacking the Alpha9 Subunit of the Nicotinic Acetylcholine Receptor Exhibit Deficits in Frequency Difference Limens and Sound Localization.
Noise Trauma-Induced Behavioral Gap Detection Deficits Correlate with Reorganization of Excitatory and Inhibitory Local Circuits in the Inferior Colliculus and Are Prevented by Acoustic Enrichment.
Excitation by Axon Terminal GABA Spillover in a Sound Localization Circuit.
Development of intrinsic connectivity in the central nucleus of the mouse inferior colliculus.
The precise temporal pattern of prehearing spontaneous activity is necessary for tonotopic map refinement.
Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map.
Tonotopic reorganization of developing auditory brainstem circuits.
Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.
For a complete publication listing, click here
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of Pittsburgh Department of Neurobiology