Department of Neurobiology

Kandler, Karl
Professor, Neurobiology
Ph.D., University of Tübingen (1993)
Address: 10016 BST3
   3501 Fifth Avenue, STE 10017
   Pittsburgh, PA, 15213-3301
Telephone: 412-624-8398
Fax: 412-648-9731

Plasticity of Auditory Circuits

Trainees in Dr. Kandler's laboratory can engage in research projects investigating mechanisms of synaptic and neuronal plasticity in the auditory system. Our lab focuses on activity-dependent circuit refinement during development and on neuronal circuit changes that occur under pathological conditions (developmental deficits, hearing loss, and tinnitus).

We use a variety of electrophysiological, live-imaging, anatomical, and behavioral methods, which we applied to normal and genetically modified mice. Together with other auditory laboratories in the Department trainees are submerged in a rich interdisciplinary environment, trainees participate in joint lab-meetings, and frequently engage in ongoing collaborative projects (with Rubio-lab, Sadagopan-lab, Seal-lab).

To discuss possible research projects please email.

Sample Publications:

Mice Lacking the Alpha9 Subunit of the Nicotinic Acetylcholine Receptor Exhibit Deficits in Frequency Difference Limens and Sound Localization.
Clause A, Lauer AM, Kandler K.
Front Cell Neurosci. 2017 Jun 15;11:167.

Noise Trauma-Induced Behavioral Gap Detection Deficits Correlate with Reorganization of Excitatory and Inhibitory Local Circuits in the Inferior Colliculus and Are Prevented by Acoustic Enrichment.
Sturm JJ, Zhang-Hooks YX, Roos H, Nguyen T, Kandler K.
J Neurosci. 2017 Jun 28;37(26):6314-6330.

Excitation by Axon Terminal GABA Spillover in a Sound Localization Circuit.
Weisz CJ, Rubio ME, Givens RS, Kandler K.
J Neurosci. 2016 Jan 20;36(3):911-25.

Development of intrinsic connectivity in the central nucleus of the mouse inferior colliculus.
Sturm J, Nguyen T, Kandler K.
J Neurosci. 2014 Nov 5;34(45):15032-46.

The precise temporal pattern of prehearing spontaneous activity is necessary for tonotopic map refinement.
Clause A, Kim G, Sonntag M, Weisz CJ, Vetter DE, Rűbsamen R, Kandler K.
Neuron. 2014 May 21;82(4):822-35.

Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map.
Noh J, Seal RP, Garver JA, Edwards RH, Kandler K.
Nat Neurosci. 2010 Feb;13(2):232-8.

Tonotopic reorganization of developing auditory brainstem circuits.
Kandler K, Clause A, Noh J.
Nat Neurosci. 2009 Jun;12(6):711-7.

Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.
Seal RP, Akil O, Yi E, Weber CM, Grant L, Yoo J, Clause A, Kandler K, Noebels JL, Glowatzki E, Lustig LR, Edwards RH.
Neuron. 2008 Jan 24;57(2):263-75.

For a complete publication listing, click here

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