Department of Neurobiology

Halfter, Willi M.
Associate Professor Emeritus, Neurobiology
Ph.D., University of Tubingen, Germany (1981)


Axonal pathfinding in the developing chick visual system

During early embryonic development, axons grow with high accuracy to specific target areas, navigating along protein cues provided by the environment. A major goal of Dr. Halfter's laboratory was to identify the proteins that are involved in the early neurite outgrowth event. Because extracellular matrix proteins are likely to play a role in axonal migration, a detailed biochemical analysis of this class of molecules in the developing chick visual system was investigated. Other investigations in Dr. Halfter's laboratory involved tissue culture experiments and transplanta-tions in live embryos in order to identify the mechanisms underlying the orientation of growing nerve fibers.


Sample Publications:

Nanoscale Topographic and Biomechanical Studies of the Human Inner Limiting Membrane.
Henrich PB, Monnier CA, Halfter W, Haritoglou C, Strauss RW, Lim RY, Loparic M.
Invest Ophthalmol Vis Sci. 2012 Mar 12.

Retinal ectopias and mechanically weakened basement membrane in a mouse model of muscle-eye-brain (MEB) disease congenital muscular dystrophy.
Hu H, Candiello J, Zhang P, Ball SL, Cameron DA, Halfter W.
Mol Vis. 2010 Jul 28;16:1415-28.

Molecular interactions in the retinal basement membrane system: A proteomic approach.
Balasubramani M, Schreiber EM, Candiello J, Balasubramani GK, Kurtz J, Halfter W.
Matrix Biol. 2010 Apr 18 (in press).

Age-dependent changes in the structure, composition and biophysical properties of a human basement membrane.
Candiello J, Cole GJ, Halfter W.
Matrix Biol. 2010 Jun;29(5):402-10.


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