Omar A. Gharbawie|
Department of Neurobiology
Center for the Neural Basis of Cognition
University of Pittsburgh
3501 Fifth Ave, STE 4069
Pittsburgh, PA 15213-3301
Organization of cortical areas that control prehension in non-human primates
Our seamless ability to manipulate objects with our hands reflects the sophistication of our sensorimotor system. My laboratory studies the functional organization of cortical areas that support manual dexterity. The overarching questions of my research program include: (1) How do frontal and parietal areas of cortex encode grasping? (2) What are the organizational principles that confer on those areas their role in grasping?
My lab uses optical imaging in awake behaving monkeys to localize cortical zones involved in grasping. The resultant maps of activation guide our placement of microelectrodes and linear electrode arrays for electrophysiological recordings. We exploit this technique to determine the actions and sensations that individual neurons encode. In addition, we characterize the flow of information across layers of cortex and between cortical zones. We use the same multi-pronged approach and neuroanatomical methods to characterize the cortical connections that support grasping.
My laboratory has multiple training opportunities. Prospective postdocs and graduate students are encouraged to contact me directly.
The origins of thalamic inputs to grasp zones in frontal cortex of macaque monkeys.
Cortical neuron response properties are related to lesion extent and behavioral recovery after sensory loss from spinal cord injury in monkeys.
Effects of muscimol inactivations of functional domains in motor, premotor, and posterior parietal cortex on complex movements evoked by electrical stimulation.
Cortical connections to single digit representations in area 3b of somatosensory cortex in squirrel monkeys and prosimian galagos.
Multiple parietal-frontal pathways mediate grasping in macaque monkeys.
Cortical connections of functional zones in posterior parietal cortex and frontal cortex motor regions in new world monkeys.
Optical imaging in galagos reveals parietal-frontal circuits underlying motor behavior.
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of Pittsburgh Department of Neurobiology